linagliptin glp 1 A Quantitative Systems Pharmacology Model of the Incretin Hormones GIP and GLP1, Glucagon, Glucose, Insulin, and the Small Molecule DPP-4 Inhibitor, GLP-1-based therapies for type 2

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2013;4:112 Nature Publishing Group

However, in A Diabetes Outcome Progression Trial (ADOPT), metformin exhibited a reduced risk of monotherapy failure compared with the sulfonylurea glibenclamide (known as glyburide in the USA and Canada) and slower rate of loss of beta cell function, although it was inferior to the thiazolidinedione rosiglitazone [20]

Feduniw, S., Korczyska, L., Grski, K., Zgliczyska, M., Bczkowska, M., Byrczak, M., Kociuba, J., Ali, M., & Ciebiera, M