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Thyroid hormone levels are linked to SHBG levels

Growth hormone may influence testosterone production through direct effects on Leydig cells rather than through LH pathway stimulation

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We also know that the lowest effective doses in the studies we've seen are 300mg of goat's rue, 600mg of shatavari, 600mg of fennel seed, and 2g of anise, and milk thistle studies have seen positive effects in doses as low as 420mg