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In addition, ASTX improved intracellular redox status by preventing the increase in hepatic reactive oxygen species (ROS) levels and by promoting a significant increase in the activity of the antioxidant enzymes catalase (CAT) and glutathione S-transferase (GST)

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Activation of Caspase-8 promotes Caspase-3-mediated apoptosis (Newton and Manning, 2016) and the NLRP3/Caspase-1 axis (pyroptosis) (Zhu et al., 2016