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The paucity of well-controlled clinical studies complicates the confirmation of whether the mechanisms identified in animals are directly applicable to humans

It improves endothelium-dependent vasodilation in patients with coronary heart disease (Trachtenberg et al., 2011)

2018;109:92633 Wiley

Healthcare provider consultation helps determine the most appropriate approach

The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications