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In a recent study [257], ferroptosis was found to play a role in SS-related SGEC death and SS pathogenesis

The main risk is dehydration during rapid dose escalation

under the brand name Scenesse, an implantable form of afamelanotide has been approved in the EU, US, and elsewhere to reduce phototoxicity in erythropoietic protoporphyria (EPP)

That additional energy expenditure mechanism is the primary driver of the 56 percentage point efficacy advantage

They found that current DPP-4 inhibitor usage did not correlate with an increased risk of these conditions compared to at least two oral antidiabetic drugs predominantly comprising metformin and sulfonylurea (3.6 vs