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This work was supported by the National Institutes of Health (R01 AR042527, R01 HL117913, R01 AI108906, R01 HL142068, and P01 HL129941 to CMW and R01 AI108891, R01 AG045779, U19 AI057266, and R01 AI129191 to JJG) and by the Encrantz Family Discovery Fund