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Understanding selenium and glutathione as antiviral factors in COVID-19: does the viral M pro protease target host Selenoproteins and glutathione synthesis

In recent years, different studies on CKD patients and animal models, such as mice, demonstrated that eryptosis, triggered by factors such as uremic toxins, inflammation, oxidative stress, and imbalances in calcium homeostasis, plays a fundamental role in the development and progression of renal anemia

CLIC, however, bind GSH covalently creating a mixed disulfide, unlike classical GSTs, which bind GSH in the active site non-covalently but with high affinity [220]

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