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Response: We thank commenters for their suggestions on how to improve the HPT requirements and the monitoring and assessment process
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For deficiency without neurological involvement or for borderline levels, oral supplementation with high-dose cyanocobalamin (1000-2000 mcg daily) is often effective, as approximately 1% of an oral dose is absorbed through passive diffusion even in the absence of intrinsic factor
doi: 10.3390/ijms23105717 [DOI] [PMC free article] [PubMed] [Google Scholar] 86
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