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Furthermore, this HG concentration was associated with a sustained increase in ROS generation (up to 96 h), suggesting it effectively induces oxidative stress, partly due to the simultaneous disruption of the antioxidant defense system [23]

Triggering mitochondrial radical release: a new function for NADPH oxidases

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The specific primers for RRM2 amplification were used as follows: Sense, 5-TTGCCTGTGAAGCTCATTGG-3 and antisense, 5-CCTCTGATACTCGCCTACTCTC-3

Molecular pathogenesis of secondary bacterial infection associated to viral infections including SARS-CoV-2