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One study on patients with major depressive disorder compared patients with hyperphagic versus hypophagic symptoms with healthy controls, finding differential effects of ghrelin depending on somatic symptom profile (Cerit et al., 2019)

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As a step therapy medication Contrave is a common step therapy requirement before insurance plans will approve GLP-1 medications like Wegovy or Zepbound

Another critical element of the maintenance phase was metabolic durability

After 40 weeks, the average drop in HbA1c was about 1.7-1.9 percentage points for participants receiving retatrutide, compared with 0.8 with the placebo