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Renal and Hepatic Function: Impaired kidney or liver function may affect IGF1 LR3 body function and clearance, possibly altering its pharmacokinetics and safety profile

Although the exact cause of subnormal serum aminotransferase levels in CKD remains controversial, possible reasons are the severity of the impairment of renal function caused by glomerular dysfunction, pyridoxine deficiency and/or the presence of an inhibitory substance in uremia

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