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Although GIP receptor activation may exert anti-emetic effects through brainstem modulation, these effects appear insufficient to completely counterbalance GLP-1 mediated emesis during early treatment and dose escalation ( In contrast, glucagon receptor activation is independently associated with nausea and vomiting through both central and peripheral mechanisms, including effects on gastric motility and autonomic signaling

Akkermansia (38.3%), Muribaculaceae (15.8%), and Eubacterium_coprostanoligenes_group (3.6%) in the XYP group

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