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Chemotherapy-induced peripheral neuropathy Many first-line chemotherapy agents used in the current clinical practice, such as platinum-based anticancer drugs (i.e., cisplatin, oxaliplatin), proteasome/angiogenesis inhibitors (bortezomib/thalidomide), vinca alkaloids (i.e., vincristine, vinorelbine) and taxanes (i.e., paclitaxel, docetaxel) cause a dose-limiting side effect called chemotherapy-induced peripheral neuropathy (CIPN) (Han and Smith, 2013

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This damage not only contributes to the diseases initiation but also activates inflammatory signaling pathways, further amplifying the inflammatory cascade

Dohil R, Carrigg A, Newbury R (2012) A potential new method to estimate tissue cystine content in nephropathic cystinosis