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Thus, the healing of the esophagocutaneous, 82 gastrocutaneous, 83 duodenocutaneous, 84 colocutaneous, 85 vesicovaginalis, 86 and rectovaginalis fistulas, 87 assessed grossly, biomechanically and microscopically means demonstration of the both external and internal fistulas healing 82 - 87 and consequently, the realization of the simultaneous healing of different tissues

Third, intestinal K-cells and pancreatic islet cells, including -cells, may also contribute to pasireotide-induced hyperglycemia 17,21,42

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These modifications serve to enhance the binding affinity of GLP-1 to the GLP-1 R and increase its resistance to DPP-4 degradation, thereby prolonging its half-life and enhancing its clinical utility