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Recent studies have shown that the three, alone or in combination, significantly upregulate GPX1 expression, effectively scavenging intracellular hydrogen peroxide and organic peroxides, reducing ROS accumulation, and enhancing antioxidant defence

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However, some key changes in cellular ApoE expression occur during AD

have shown that mechanical load in vivo promotes the production of O 2 in mitochondria of chondrocytes, and the expression of SOD1 and SOD2 in mitochondria decreases, while mitochondrial dysfunction induced by superoxide in mitochondria will further lead to cartilage degeneration (Scott et al., 2010)