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Endocrinology 140:16871694 Reimann F, Gribble FM (2002) Glucose sensing in GLP-1 secreting cells

For obesity treatment, higher maintenance doses within the labeled range consistently produce the greatest, most long-term weight loss in randomized trials: Semaglutide 2.4 mg led to about 15 percent average weight loss at 68 weeks in STEP trials

Watch for symptoms of hypoglycemia, especially in the hours following injection

This article breaks down how each drug works, what trials show so far, where they differ in side effects and heart health, and how to think about choosing between them

Your healthcare provider can work with you to find the most appropriate treatment approach that balances effective diabetes management with acceptable tolerability