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ScGrx7 and PfGrx both have typical ping-pong kinetics with GSSCys and GSH and cannot be saturated at infinite substrate concentrations in accordance with previous results from GSSEtOH assays on ScGrx7 (ref

in most studies, these mechanisms are not distinguished

Much of this evidence has recently been reviewed in detail elsewhere [2,3].A recent exhaustive review of the literature complete with citation tracking demonstrated that, within the medical profession, APAP is widely considered safe when used as directed in the pediatric population [5]

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The study found that while low to moderate doses (2.5-250 g) provided some benefit, daily doses of around 500 g or more were required to restore healthy B12 levels