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Regulatory changes : The FDA has been tightening rules around compounding, especially for GLP-1 medications, so availability can shift quickly

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Microdosing may be considered when standard starting doses create barriers to tolerance or continuation

Surgical outcomes: A preclinical model found a 47% reduction in periprosthetic joint infections with GLP-s compared to insulin and a 61% reduction compared to untreated diabetic controls

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