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Semaglutide creates a significant calorie deficit, often 500 to 1,000 calories below maintenance, and without adequate protein stimulus, the body sacrifices muscle to fill the gap

Others affect growth hormone, recovery, libido, body composition, or metabolic markers that people associate with "low T" symptoms without meaningfully raising testosterone

This results in a better testosterone-to-estrogen ratio, which is just as important, if not more so, than the raw testosterone number itself

However, your health insurer may not cover these drugs unless you have an obesity-related medical problem, such as high cholesterol or high blood pressure

Unlike GLP-1, GIP has a more direct effect on fat metabolism, promoting lipid storage and fat accumulation