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Indications Escitalopram is FDA-approved to treat the following disorders (8): Depressive disorder in adults and adolescents, ages 12-17 Generalized anxiety disorder for adults and children, ages 7+ Escitalopram is prescribed off-label for (8): Social anxiety disorder Obsessive-compulsive disorder Panic disorder Posttraumatic disorder Premenstrual dysphoric disorder Vasomotor symptoms associated with menopause Mechanisms of Action and Pharmacokinetics Escitalopram binds to the presynaptic neurons sodium-dependent serotonin transporter protein (SERT)

Glutamate excitotoxicity resulting from excessive glutamate release following noise overstimulation leads to an influx of cations such as Ca 2+ across the post-synaptic membrane

and a scheme of the dielectric barrier discharge can be found in the ESI 54

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It is preventable by starting slow and using appropriate concentrations