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Investigated the effects of natural or plant-derived products on psoriasis-related mechanisms

Topical vs Injectable Tolerability Topical GHK-Cu appears better tolerated than injectable forms, with topical side effects typically limited to mild redness, itching, or irritation at application site and rare copper uglies phenomenon (anecdotal accelerated skin aging appearance due to potential MMP upregulation, not well-studied)

Mercury, cadmium, lead, and arsenic are all known to impair mitochondrial bioenergetics by disrupting the electron transport chain, generating reactive oxygen species (ROS), and compromising membrane integrity (Sun et al., 2022

However, these comparisons are speculative and have not been validated in robust human clinical trials

Reproduction (2002) 123:21726