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Think of it this way: a systemic injection is like sending a highly skilled repair crew into the building's main entrance

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TGF family of proteins are involved in tumor initiation and progression, cell proliferation, angiogenesis, epithelial to mesenchymal transition, invasion and inflammation (59)

Importantly, these findings demonstrate that while the depletion of glutamate by GCLC is a metabolic vulnerability under nutrient replete conditions, we find that it confers an advantage under cysteine starved conditions