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Indeed, women affected by premature menopause under 40 years of age and who did not receive estrogens treatment show an increased risk of developing cardiovascular and neurodegenerative disorders, which correlate with an increase in mortality (Shuster et al., 2010)

The binding of rapamycin to FK506 binding protein 12 (FKBP12) and its complex formation were found to be particularly effective in inhibiting mTOR, especially the mTORC1 isoform (223225)

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Repeated IM injections are painful and inconvenient, and other local side effects such as tissue irritation or fibrosis at injection sites are also concerns, leading to low long-term patient compliance (Farr and Xiong, 2021)