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This includes variations between the type of GLP-1 agent, dose, duration of therapy or underlying patient phenotype such as body mass and metabolic rate, patients age, muscle activity, previous toxin treatments, and/or dosage

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conversely, the stalk and the extracellular half of helix II move 1012 away from the orthosteric pocket (Fig

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Because coadministration of a high-fat meal with JANUVIA had no effect on the pharmacokinetics, JANUVIA may be administered with or without food