Over a mean follow-up period of 39.8 months, semaglutide demonstrated superiority over placebo in reducing the composite endpoint of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke among overweight or obese patients with established cardiovascular disease, but without diabetes
Though that relationship is still being investigated, essentially the inability to control the impulse to eat a big piece of pie despite being full is the same kind of inability that may fuel binge drinking and other addictive behaviors
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Furthermore, there have been multiple case reports of retained stomach contents or regurgitation following approved fasting protocols for patients on GLP-1RAs 61,62,63,64,65,66,67,68,69,70,71
These results are consistent with previous studies [30, 39]