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For further quantitative analysis, the medium in the basolateral chamber was collected at 0.5, 1, 2, 4, and 8 h after the addition of liposomes, and the permeated DiD fluorescence intensity was measured with an Infinite F200 pro multimode reader (Tecan, Switzerland)

Two studies investigated animal models of comorbid depression and epilepsy 159,161 : one showed that exendin-4 led to an increase in frequency of absence seizures as well as depressogenic and anxiogenic responses 159 , while the other saw a decrease of depression-like behavior for liraglutide irrespective of concurrent use of the antiepileptic levetiracetam 161

2015 Jan-Feb;55(1-2):9-15

These findings indicate that semaglutide may be a potential candidate for future clinical trials targeting cocaine use disorder, a condition for which no approved medication currently exists

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