Without adequate collagen production and proper organization of collagen fibers, wounds heal with reduced strength and may be more prone to reopening or developing problematic scars
FIGURE 3 Overall, most studies indicate that virtually all cells involved in skin repair (fibroblasts, keratinocytes, inflammatory cells, tissue stem cells, and vascular endothelial cells) express both ER and ER and are direct targets of E2 (Pomari et al., 2015
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peripheral vascular thrombosis Hematological : Polycythemia vera (a rare type of blood cancer) Gastrointestinal : Mild, transient diarrhea Dermatological : Itching
To develop more effective treatments in the future, cognition recognition and utilizing more accurate assessment methods are required