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For each of our outcomes of interest, a repeated measure within-between interaction was performed with a group, time (i.e., pre/post), and group by time interaction as the explanatory variables and a random effect for the individual was performed using the lme4 package 51

Ex vivo pancreatic islet GSIS assay Pancreatic islets were isolated from WT or GLP-1R knockout C57BL/6 mice 99 using collagenase perfusion 78

In an 8-week study using low-dose liraglutide (0.6 mg/day) in patients with type 2 diabetes no weight or fat loss was produced, but both fasting and postprandial glucose were substantially reduced, but neither fasting nor postprandial insulin (or C-peptide) response was increased [19]

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Such disorders may often lead to more severe problems, such as perforations, blockages, and gastric cancer