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doi:10.1089/10755530260127970
2013 (PMID 23055539), which carries a 2021 Expression of Concern
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Plasma levels of GHK-Cu are highest in young adults (approximately 200 ng/mL) and decline significantly with age (dropping to approximately 80 ng/mL by age 60)
Notably, tirzepatide may reduce the effectiveness of oral contraceptives during dose escalation due to delayed gastric emptying
This might be due to the restricted quantity of BER that can be captured in the phospholipid layer of anionic liposomes besides, the hydrophilic drug is typically encapsulated with low efficiency due to the presence of a large volume of external aqueous hydration medium, So, very little content of hydrophilic drug can be entrapped within the aqueous core of the liposome [75]
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