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Methionine combines with ATP to form S-adenosylmethionine, or SAM

High concentrations

Many people wrongly think they are allergic or stop using it for these reasons. These side effects are often known as the retinoid uglies, and they can be challenging, but theyre not insurmountable

A study in adults aged 70 and older showed increased heteroplasmy linked to an increased depression score.[ref] Rare mitochondrial mutations that cause mitochondrial diseases are also linked to major depressive disorder.[ref] In fact, one study of people with hereditary (genetic) mitochondrial diseases showed that 54% had major depressive disorder and 17% had bipolar disorder.[ref] Outside of the mitochondrial genome, genes in the nuclear genome that code for proteins in the mitochondria are also linked to depression