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With major or rapid weight loss, several structural changes occur: Fiber breakdown: The elastin and collagen fibers (which give skin its snap) become damaged and break

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3841 Unresolved Role of GLP-1RAs in Heart Failure with Reduced Ejection Fraction Unlike the positive results reported for GLP-1RAs in HFpEF, findings from dedicated trials in heart failure with reduced ejection fraction (HFrEF) report neutral findings

It produces worse side effects, more discontinuations, and often slower progress because severe GI symptoms prevent adequate nutrition and hydration