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Curious to learn more about the effect of GLP-1 on appetite, in 1998 Holst and collaborators at the University of Copenhagen undertook a placebo-controlled, randomised study with 20 healthy young men between the ages of 20 and 31

Why It Happens Diarrhea can occur with GLP-1 medications, particularly during the first few weeks of treatment or after dose increases

Optimized the lipid-to-peptide ratio to prevent leakage in the presence of surfactants found in shampoos

Plateaus lasting 48 weeks are normal and often resolve with behavioral adjustments or dose optimization

But the null finding is notable because it suggests that GLP-1 appetite suppression may already be near the ceiling of what appetite reduction can achieve, leaving little room for phentermine to add benefit