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Patients who receive a combination of anesthetic and steroid medication may notice a slight increase in pain after the injection as the numbing medicine wears off and the cortisone starts to take effect

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Among other metabolites that exhibited significant changes in the metabolomic analysis, spermidine (ratio: 1.3), a polyamine having strong anti-oxidant activity, acts as an intrinsic free radical scavenger

A second concern involves drug-drug interactions and metabolic unpredictability

Some describe feeling like they've come down with a mild flu that has no other symptoms