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Preclinical studies also indicate that tanycytes, specialized glial cells within the CNS, may facilitate the transportation of peripheral GLP-1RAs, such as semaglutide, into the CNS, bypassing the blood-brain barrier to access appetite-regulating hypothalamic regions such as the arcuate nucleus (60, 61)

Peptide administration directly into muscle tissue

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An exploratory signal suggested a potential lower risk of heart failure hospitalization with semaglutide compared to dapagliflozin

Therefore the results can just be seen as a rule of thumb and are without any guarantee