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Since cancer is a chronic disease, T-cells within the lymph nodes are continuously exposed to cancer antigens resulting in the upregulation of CTLA-4 on their cell surface and inhibition of proper T-cell activation, disrupting anti-tumor cytotoxic T-cell functions that results in T-cell anergy (162164)

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Grigoletto FernandesIAlves de BritoCSilva Dos ReisVMSatoMNZanete PereiraN

Early researchers noticed that GLP-1 powerfully and appropriately stimulated insulin only when glucose levels were high, meaning it lowered blood sugar without causing dangerous hypoglycemia, says New York internist and longevity expert Amanda Kahn, MD