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GLP-1 medications like Semaglutide and Tirzepatide were originally developed to manage type 2 diabetes

Patients treated with GLP-1 receptor agonists had a 41% lower risk of initiating chronic opioid therapy compared to non-users

Deterioration of BBB form and function is a feature part of healthy aging, but it is worsened in many neurodegenerative disorders and is a hallmark of cognitive decline

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Since its clinical application in 1957, metformins cornerstone status has remained consistent and it is still the first-line preferred treatment for type 2 diabetes mellitus (T2DM) side by side with lifestyle (Montvida et al., 2018