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In trisomic cells, an interesting study showed cytoplasmic dsDNA activated the cGAS-STING signalling (Krivega et al., 2021)

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(1) modulating antigen presentation to lymphocytes, thereby influencing cytokine production and type of response (cellular or humoral) that develops, (2) enhancing proliferation of lymphocytes, thereby increasing magnitude of response, (3) enhancing killing activity of cytotoxic T cells and NK cells, and (4) regulating apoptosis, thereby maintaining control of the immune response

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