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Crucially, the same analysis finds that Suggested policy Negotiate GLP-1 prices down (Medicare/Medicaid coverage tied to a bundled program rather than the drug alone), fund oral-GLP-1 access to reach the inactive tier, and the highest-ROI structural move reclassify prevention as reimbursable so payers cover strength-training referrals, dietitian time, and CGMs the way they cover statins

(December 2005)

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Further evidence was provided by another clinical study which suggested that sitagliptin could reduce BP under low-dose enalapril treatment without effects on cardiac rhythm and hormonal level, but increased hypertensive response in combination with high-dose enalapril accompanied by increasing heart rate and norepinephrine concentration