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Semaglutide can also cause side effects like nausea, vomiting, diarrhea, stomach pain, and constipation

Nausea (41%), diarrhea (23%), vomiting (20%), and constipation (18%) are the most frequently reported

Where to Give B12 Shot Intramuscular injections can be given in several locations on the body, with the most common being the upper buttocks, the shoulder, and the thigh

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A randomized, double-blind, placebo-controlled trial in 153 older adults taking the antidepressant citalopram found daily supplementation with 500 g vitamin B 12 , 2 mg of folic acid, and 25 mg of vitamin B6 for one year did not reduce the severity of depressive symptoms but increased the response to drug treatment and helped to prevent symptom relapse (112), suggesting B-vitamin supplementation might provide some benefit as an adjunct therapy