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Cells were spun at 4C for 20 min to pellet, and resuspended in lysis buffer (50 mM NaH2PO4, 300 mM NaCl, 10 mM imidazole, pH = 8)

Mazdutide Mazdutide is a once-weekly synthetic peptide analog based on the mammalian oxyntomodulin (OXM) scaffold, also known as IBI362 or LY3305677

This biochemical mechanism supports the observed neuroprotective effects, as NAC enhances intracellular glutathione production, thereby reinforcing the cellular redox system, promoting detoxification of HNE, and ultimately protecting neurons from oxidative damage

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