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Graphical Abstract 1 Introduction Heart failure (HF) is the final stage of various cardiovascular diseases, affecting more than 26 million individuals worldwide, with a 5-year mortality rate nearing 50% ( As a highly energy-demanding organ, the heart relies heavily on mitochondria to continually generate adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS), with fatty acid oxidation (FAO) supplying about 60%90% of this energy (Yamamoto and Sano, 2022)

Presence of cytosolic peroxiredoxin 2 in the erythrocyte membrane of patients with hereditary spherocytosis

Chronic plaque psoriasis is associated with increased arterial stiffness

Glutamine is mainly synthesized by glutamine synthetase (GS) and hydrolyzed by glutaminase (GLS)

Glutathione is promoted as a safe alternative because it does not cause any harm to your skin