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The association is an ongoing area of scientific debate and clinicians should be aware of the issue in their clinical decision-making, especially given that most short-term fevers in pregnant women and young children do not require medication. Makary also reminds clinicians that acetaminophen is the safest over-the-counter medication option in pregnancy among all analgesics and fever reducers and that aspirin and ibuprofen have well-documented adverse impacts on the fetus

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The analysis compared the frequency of these adverse events in patients treated with either semaglutide or tirzepatide against control groups receiving placebos