The abnormal signal pathways will lead to excessive production of FFAs and ROS in adipocytes and hepatocytes, which is a milestone of the first step to develop MASH (Portincasa et al., 2024)
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The same finding had been reported by a prior larger meta-analysis (6,914 patients with overweight or obesity and T2DM) over 8 studies 184,185,189,190,191,192,193,194 , but only when the largest study that also included non-diabetic participants 193 was excluded in a sensitivity analysis 195
About the research team The study was led by Professor Ryan Au Yeung Shiu-lun, Assistant Professor in the School of Public Health, HKUMed
Gluckman and his colleagues provide a clearer picture for clinicians and patients alike, guiding better-informed decisions in the fight against obesity