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Insulin and sulfonylureas (i.e., glipizide) are considered high risk for hypoglycemia in older adults and should be considered for deprescribing where appropriate

Unlike simply increasing the dose of a single agonist, combining two complementary signalling pathways allows research to model a stronger overall effect with a controllable adverse-event profile

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L-carnitine, which is the critical metabolite in the transport of long-chain FAs into the mitochondria for subsequent -oxidation, is downregulated in the lungs of mice with emphysema (Karlic et al., 2002