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541 The BBB controls the entry of circulating substances and cells into the brain, maintaining the stability of normal brain function and serving as the primary barrier for iron entry

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Seek same-day medical advice if you experience: Sudden, severe pain in a joint, particularly the big toe, ankle, or knee, often developing overnight Visible swelling, redness, and warmth over the affected joint Extreme tenderness making it difficult to bear weight or tolerate even light touch (such as bedsheets) Fever or feeling generally unwell accompanying joint symptoms, which may indicate infection (septic arthritis) requiring urgent assessment (contact NHS 111, an urgent treatment centre, or A&E) Contact your GP promptly if: You have a known history of gout and experience symptoms suggestive of a flare-up Joint symptoms are moderate but persistent and affecting daily activities You have recurrent episodes of joint pain since starting Ozempic You are uncertain whether symptoms represent gout or another condition Arrange a routine appointment to discuss: Preventive strategies if you have a history of gout before starting Ozempic Uric acid monitoring if you are at higher risk (family history, previous gout, kidney disease) Medication adjustments if you experience frequent flare-ups despite preventive measures It is important to note that acute gout attacks should not necessarily lead to discontinuation of Ozempic

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