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Reduction of laxity loose, sagging skin especially with moderate loss of elasticity

However the incidence of acute pancreatitis with treatment is quite rare with 0.2 events per 100 person-years in the STEP1 trial

That makes it hard to verify safety

Despite such extensive analyses, and apart from a pioneering screen that revealed an interaction between glp-1 and some extracellular matrix components 57 , it remained unclear how the extracellular matrix composition affected Notch signalling

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