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2025 Meta-Analysis: Pooled Evidence A systematic review and meta-analysis published in PMC (2025), pooling 2 RCTs and 5 retrospective cohorts, confirmed tirzepatides superiority with an overall mean difference of 4.23 kg in favour of tirzepatide (95% CI: 3.225.25

Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism

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