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Membrane conductance was measured in voltage clamp experiments by applying a series of 1.2-s voltage ramps from 90 to 50 mV (holding potential 70 mV)

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The classic Bouwstra model describes the layer as a brick-and-mortar arrangement: corneocytes (the "bricks") are tightly packed flattened cells held together by intercellular lipids (the "mortar") arranged in lamellar bilayers