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Last, we accounted for overall duration in care (in years [continuous]) and propensity to use health care (number of outpatient visits in the 2 years before baseline [continuous]) (eTables 4 and 5 in Supplement 1)

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What we prioritize first Before focusing on GLP-1 dosing terminology, we prioritize the clinical fundamentals that have the strongest relevance to cognitive longevity: blood pressure optimization ApoB, LDL, triglyceride, and lipoprotein(a) risk assessment insulin resistance and glucose-pattern evaluation visceral fat and body-composition measurement resistance training and aerobic fitness sleep quality and sleep apnea evaluation when appropriate hearing and vision support nutrition quality and protein adequacy alcohol moderation inflammation and immune-metabolic context hormone evaluation when clinically indicated social connection, cognitive engagement, and meaningful activity None of these interventions is glamorous by itself

Endocrinology (2016) 157(3):124857

At the same time, Ex-4 inhibits the expression of NF-B, subsequently reducing the expression and secretion of its downstream factor, stromal cell-derived factor-1 (SDF-1)