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Nat Rev Endocrinol 22 , 242254 (2026)

Vanholder, R., Schepers, E., Pletinck, A., Nagler, E

That is why every formulation we offer is subjected to stringent validation and certification protocols

73 Another review of randomized controlled trials and epidemiological studies found caffeine prolonged sleep latency (ie, the amount of time it takes to fall asleep), reduced total sleep time and sleep efficiency, and worsened perceived sleep quality